Editorial: Sample preparation - a necessary evil or the key to proteomics?
30 April 2009
Over the years, the main focus of proteomics has been on technological aspects such as capacity and dynamic range of 2D gels, masspectrometry resolution and sensitivity. Enormous amounts of money and effort have been spent on this work while the softer side of proteomics; study design, sample preparation and reproducibility have been left out in the cold. The old saying "garbage in, garbage out" holds as true for proteomics as other parts of life, no matter how many millions of Euros you spend on for instance mass spectrometers. In order to fix proteomics and release its full inherent potential these softer aspects must be allowed a place on centre stage.
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