Fixing Proteomics Campaign

13 November 2009

There's been quite a few papers and articles added to this site demonstrating the need for Fixing Proteomics efforts and showing latest studies aimed at overcoming the issues facing proteomics.

For example the HUPO test sample study revealed common problems in MS-based proteomics and a commentary by Matthias Mann in the five year anniversary special edition of Nature Methods that starts with "The potential of mass spectrometry-based proteomics to advance biology is nearly unlimited, but so is its potential for generating bad data..."

On a positive note news from the latest on improving measurements in clinical proteomics from the NCI-CPTAC network. There was a paper published in June on how "existing MS technologies have been used to a multilaboratory study to assess reproducibility, recovery, linear dynamic range and limits of detection and quantification of multiplexed, MRM-based assays" (linked here). Another paper from this network, published in Mol Cell Proteomics last month, has practical advice for benchmarking LC-MS platform performance.