Editorials
We've been asking Fixing Proteomics Supporters and Founders to provide though-provoking editorials that highlight the challenges facing proteomics and provide proof that it's possible to produce reproducible results. We'll add more as we get them but if you have an interesting idea email me and we'll get it up here.
Sample preparation - a necessary evil or the key to proteomics?
Over the years, the main focus of proteomics has been on technological aspects such as capacity and dynamic range of 2D gels, mass spectrometry resolution and sensitivity. Enormous amounts of money and effort have been spent on this work while the softer side of proteomics; study design, sample preparation and reproducibility have been left out in the cold. The old saying "garbage in, garbage out" holds as true for proteomics as other parts of life, no matter how many millions of Euros you spend on for instance mass spectrometers. In order to fix proteomics and release its full inherent potential these softer aspects must be allowed a place on centre stage. Continue reading...
Flat pack assembly and mass spectrometry
Have you ever wondered at the various types of screw heads you find in a typical piece of flat-packed furniture? When we're assembling our furniture, we typically don't care about the idiosyncrasies of screw types - after all, we're too busy figuring out the assembly manual. But when we are planning proteomics experiments, we do need to realize the properties of the technologies we're using. Continue reading...